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在氧气存在下神经和肾毒性化合物二氯乙炔的分解:新型产物的分离与鉴定

Decomposition of the neuro- and nephrotoxic compound dichloroacetylene in the presence of oxygen: separation and identification of novel products.

作者信息

Reichert D, Metzler M, Henschler D

出版信息

J Environ Pathol Toxicol. 1980 Sep;4(2-3):525-32.

PMID:7462916
Abstract

Dichloroacetylene (DCA) shows pronounced nephrotoxic effects in several animal species and is neurotoxic in humans. It is a chemically highly reactive compound that decomposes spontaneously in the presence of oxygen. The chemical decomposition of DCA has been studied in order to understand the role of the decomposition products for the toxic effects of DCA. Seven compounds were identified by their mass spectra and by comparison with authentic reference materials. Among these were phosgene, hexachlorobutadiene, and other reactive products (e.g., trichloroacetyl chloride and trichloroacryloyl chloride), which may explain, in part, the toxicity of DCA.

摘要

二氯乙炔(DCA)在多种动物物种中表现出明显的肾毒性作用,对人类具有神经毒性。它是一种化学性质高度活泼的化合物,在有氧气存在的情况下会自发分解。为了了解分解产物对DCA毒性作用的影响,人们对DCA的化学分解进行了研究。通过质谱分析并与标准参考物质进行比较,鉴定出了七种化合物。其中包括光气、六氯丁二烯以及其他活性产物(如三氯乙酰氯和三氯丙烯酰氯),这些可能部分解释了DCA的毒性。

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引用本文的文献

1
Formation of dichloroacetylene from trichloroethylene in the presence of alkaline material--possible cause of intoxication after abundant use of chloroethylene-containing solvents.在碱性物质存在下由三氯乙烯形成二氯乙炔——大量使用含氯乙烯溶剂后中毒的可能原因。
Arch Toxicol. 1984 Dec;56(2):74-7. doi: 10.1007/BF00349074.