Lennard E S, Dellinger E P
J Fam Pract. 1981 Mar;12(3):461-7.
Antibiotic administration can effectively reduce the risk of postoperative wound infection under specific circumstances. Maximal protection is obtained when an antibacterial concentration of a bacteriologically appropriate antibiotic regimen is circulating within target tissues at the time of bacterial contamination. This protection is obtained during a finite period, usually not exceeding four hours following bacterial seeding of tissues. The preservation of intact host defense mechanisms is of ultimate importance in preventing wound infection. When defenses are compromised or when an inoculum is of a size that can overwhelm host defenses, the perioperative administration of antibiotics can significantly reduce infection risk. However, antibiotic use must not lead to a relaxation of good surgical judgment and technique.
在特定情况下，使用抗生素可有效降低术后伤口感染的风险。当细菌污染时，目标组织中循环着具有细菌学适宜抗菌浓度的抗生素方案，即可获得最大程度的保护。这种保护在有限的时间段内实现，通常在组织接种细菌后不超过四小时。完整宿主防御机制的维持对于预防伤口感染至关重要。当防御功能受损或接种菌量过大以至于能够压倒宿主防御时，围手术期使用抗生素可显著降低感染风险。然而，抗生素的使用绝不能导致放松良好的手术判断力和技术要求。
