McManus E C, Olson G, Pulliam J D
J Parasitol. 1980 Oct;66(5):765-70.
Restricted medication experiments were done to correlate time of arprinocid medication with developmental stages of the life cycle of Eimeria tenella. By the criterion of histopathology and using a massive inoculum (10(6) sporulated oocysts), 50 ppm was partially active and 70 ppm was fully active against the first asexual generation when medication was delayed until day 1. When medication was delayed until day 2, full activity was demonstrated against the late, first asexual generation. When medication was delayed until day 3, definite but less complete activity was shown against the late, second asexual generation. Using the conventional efficacy parameters and with an inoculum of 5 X 10(4), full activity occurred with 50 ppm when medication was started up to day 2. Essentially full activity was observed with 60 ppm started at day 3. The combined results of the two tests are interpreted to indicate high activity against both the first and second asexual generations. Medication with 70 ppm changed the wall-forming bodies of the macrogamete. They were indistinct and less intensely eosinophilic than controls.
进行了限制用药实验，以关联阿普林诺西德用药时间与柔嫩艾美耳球虫生命周期发育阶段的关系。依据组织病理学标准并使用大量接种物（10⁶个孢子化卵囊），当用药延迟至第1天时，50 ppm具有部分活性，70 ppm对第一代无性生殖完全有活性。当用药延迟至第2天时，对第一代无性生殖后期表现出完全活性。当用药延迟至第3天时，对第二代无性生殖后期显示出确定但不太完全的活性。使用传统疗效参数并接种5×10⁴个卵囊，当在第2天之前开始用药时，50 ppm有完全活性。在第3天开始使用60 ppm时观察到基本完全活性。两项试验的综合结果表明对第一代和第二代无性生殖均具有高活性。用70 ppm用药改变了大配子的壁形成体。它们不清晰，嗜酸性比对照弱。
