McQuistion T E, McDougald L R
Vet Parasitol. 1981 Oct;9(1):27-33. doi: 10.1016/0304-4017(81)90004-2.
Halofuginone and arprinocid, new anticoccidial drugs, were tested to determine the time of peak activity in the life cycle of Eimeria and whether they were coccidiocidal or coccidiostatic. Halofuginone was completely effective if medication was initiated by Day 3 postinoculation, but only partly effective if given on Days 4-7. Arprinocid was effective if given on Days 2-7 postinoculation, but only partly effective if given on Days 3-7. When medication was started on Day 0 and withdrawn on various subsequent days, good activity was recorded with halofuginone if the drug was given up to Day 1 postinoculation, but arprinocid required feeding up to Day 4 postinoculation. In other studies, medication was given until Days 6 or 7 postinoculation, then discontinued, to allow further development of coccidia that were arrested by the drug. With halofuginone, the oocyst passage was low with E. tenella and E. maxima but moderate with E. mivati. With arprinocid, oocyst passage was low with E. maxima and E. mivati but moderate with E tenella. These results suggest that halofuginone is active over a broader part of the life cycle than arprinocid, but both drugs had a predominantly coccidiocidal action.
对新型抗球虫药常山酮和阿普立西进行了测试，以确定其在艾美耳球虫生命周期中的活性峰值时间，以及它们是杀球虫药还是抑球虫药。如果在接种后第3天开始用药，常山酮完全有效，但在第4 - 7天给药则仅部分有效。阿普立西在接种后第2 - 7天给药有效，但在第3 - 7天给药则仅部分有效。当在第0天开始用药并在随后不同天数停药时，如果常山酮在接种后第1天之前给药，则记录到良好的活性，但阿普立西需要在接种后第4天之前持续给药。在其他研究中，给药至接种后第6天或第7天，然后停药，以允许被药物抑制的球虫进一步发育。使用常山酮时，柔嫩艾美耳球虫和巨型艾美耳球虫的卵囊排出量较低，但微小艾美耳球虫的卵囊排出量中等。使用阿普立西时，巨型艾美耳球虫和微小艾美耳球虫的卵囊排出量较低，但柔嫩艾美耳球虫的卵囊排出量中等。这些结果表明，常山酮在生命周期中比阿普立西具有更广泛的活性，但两种药物都主要具有杀球虫作用。
