Warrell M J, Tobin J O, Wald N J
J Med Microbiol. 1981 Feb;14(1):159-62. doi: 10.1099/00222615-14-1-159.
Early antenatal serum specimens were collected from 25 women who subsequently gave birth to infants with anencephaly or spina bifida. Fluorescent-antibody test for influenza-specific IgA and IgM antibodies, although shown to be reliable for the detection of recent influenzal infection, failed to demonstrate such infection in any of these women. Early infection was detected in one of 50 control women who gave birth to a healthy infant. The results indicate that influenzal infection in pregnancy was not a major cause of neural-tubal defects in Oxford during 1972--76, if a cause at all.
从25名随后产下无脑儿或脊柱裂婴儿的妇女身上采集了早期产前血清样本。流感特异性IgA和IgM抗体的荧光抗体检测，尽管已证明对检测近期流感感染可靠，但在这些妇女中均未显示有此类感染。在50名产下健康婴儿的对照妇女中，有1人检测出早期感染。结果表明，1972 - 1976年期间在牛津，孕期流感感染即便算得上神经管缺陷的一个病因，也不是主要病因。
