Owen J S, Gillett M P
Scand J Clin Lab Invest Suppl. 1978;150:194-8.
Plasma and erythrocyte lipid abnormalities occur in chronic human schistosomiasis mansoni and appear to be related to mild lecithin:cholesterol acyltransferase (LCAT) deficiency. Plasma LCAT activity is about 50% lower than normal in decompensated hepatosplenic schistosomiasis, whilst the plasma concentrations of cholesteryl ester and lysolecithin and decreased and that of lecithin increased in the earlier hepatointestinal and compensated hepatosplenic forms of the disease as well as in the later decompensated stage. Plasma lipoproteins are also altered in schistosomiasis. Agarose gel electrophoresis showed reduced alpha and pre-beta lipoproteins, whilst other studies consistently showed that lipoproteins from patient plasma are better substrates for LCAT than those of normal plasma. Erythrocyte cholesterol is increased in all forms of the disease, and the cells show increased resistance to lysis either in hypotonic media or in 0.3 M glycerol. The severity of these lipid changes clearly shows a gradation through the successive stages of the disease. In the experimentally infected mouse LCAT deficiency does not seem to be a feature of the disease, but several significant changes in plasma and erythrocyte lipids occur which contrast with those seen in human schistosomiasis.
在慢性曼氏血吸虫病患者中会出现血浆和红细胞脂质异常，且这些异常似乎与轻度卵磷脂胆固醇酰基转移酶（LCAT）缺乏有关。在失代偿性肝脾型血吸虫病中，血浆LCAT活性比正常水平低约50%，而在疾病早期的肝肠型和代偿性肝脾型以及后期失代偿阶段，血浆胆固醇酯和溶血卵磷脂浓度降低，卵磷脂浓度升高。血吸虫病患者的血浆脂蛋白也会发生改变。琼脂糖凝胶电泳显示α脂蛋白和前β脂蛋白减少，而其他研究一致表明，患者血浆中的脂蛋白比正常血浆中的脂蛋白更易成为LCAT的底物。在该病的所有类型中，红细胞胆固醇均升高，且细胞在低渗介质或0.3M甘油中表现出对裂解的抵抗力增强。这些脂质变化的严重程度在疾病的连续阶段呈现出明显的梯度变化。在实验感染的小鼠中，LCAT缺乏似乎不是该病的特征，但血浆和红细胞脂质会出现一些显著变化，这与人类血吸虫病中所见的情况形成对比。
