铸造厂中的多环芳烃。

Polycyclic aromatic hydrocarbons in foundries.

作者信息

Schimberg R W, Pfäffli P, Tossavainen A

出版信息

J Toxicol Environ Health. 1980 Sep-Nov;6(5-6):1187-94. doi: 10.1080/15287398009529936.

Abstract

Air and dust samples from iron foundries were analyzed for polycyclic aromatic hydrocarbons (PAH) by glass capillary gas chromatography, mass spectrometry, and thin-layer chromatography. Fifty compounds were identified as PAH, among them known carcinogens and cocarcinogens. Benzo[a]pyrene (B[a]P) was measured quantitatively. The results were grouped according to the types of organic additives in the molding sand. The B[a]P concentrations were highest in foundries using coal tar pitch and in the work phases of shake-out, casting, and molding. In the Ames assay the dust samples showed mutagenic activity, but in most cases lower than that calculated from the concentration of B[a]P. It is suggested that B[a]P can be used as a hygienic marker in branches of industry with PAH problems.

摘要

采用玻璃毛细管气相色谱法、质谱法和薄层色谱法，对铸铁厂的空气和粉尘样本进行多环芳烃（PAH）分析。共鉴定出50种PAH化合物，其中包括已知的致癌物和促癌物。对苯并[a]芘（B[a]P）进行了定量测定。结果根据型砂中有机添加剂的类型进行分组。在使用煤焦油沥青的铸造厂以及落砂、浇铸和造型工作阶段，B[a]P浓度最高。在艾姆斯试验中，粉尘样本显示出诱变活性，但在大多数情况下低于根据B[a]P浓度计算得出的活性。建议将B[a]P用作存在PAH问题的工业部门的卫生指标。