砷化合物与癌症。

Arsenic compounds and cancer.

作者信息

Axelson O

出版信息

J Toxicol Environ Health. 1980 Sep-Nov;6(5-6):1229-35. doi: 10.1080/15287398009529941.

Abstract

Exposure to arsenic compounds has been epidemiologically associated with various types of cancers, particularly cancer of the lung among copper smelters and pesticide workers, whereas skin cancers and liver angiosarcomas have been associated with ingestion of arsenic for treatment of skin disorders, especially psoriasis. Attempts to reproduce cancer in animals have been mainly unsuccessful, however. Experimental evidence suggests that arsenic inhibits DNA repair; this might help to explain the somewhat conflicting observations from epidemiologic studies and animal experiments with regard to carcinogenicity, and perhaps also cardiovascular morbidity related to arsenic exposure.

摘要

流行病学研究表明，接触砷化合物与多种癌症相关，尤其是铜冶炼工人和农药工人中的肺癌，而皮肤癌和肝脏血管肉瘤则与摄入砷治疗皮肤疾病（尤其是牛皮癣）有关。然而，在动物身上重现癌症的尝试大多未成功。实验证据表明，砷会抑制DNA修复；这或许有助于解释流行病学研究和动物实验在致癌性方面以及与砷暴露相关的心血管发病率方面存在的一些相互矛盾的观察结果。