Bland K I, Buchanan J B, Mills D L, Kuhns J G, Moore C, Spratt J S, Polk H C
JAMA. 1981 Mar 13;245(10):1037-42.
The five-year screening experience for 10,128 asymptomatic women whose conditions were evaluated at the Louisville Breast Cancer Detection Demonstration Project disclosed 163 breast carcinomas in women aged 35 to 74 years. Thirty-four percent of patients with proved carcinoma were younger than 50 years; 31% with infiltrating carcinoma had axillary metastases at the time of diagnosis. In younger patients, carcinomas disclosed at intervals between scheduled screenings were more commonly metatastic. Minimal breast cancer was more prevalent in the screened population (29%) than the unscreened population (less than 5%), and appeared with similar frequency in screenees of each age category. Screening women younger than 50 years allow earlier diagnosis and treatment of breast cancer in a favorable stage that is comparable with that noted in the older screenees.
在路易斯维尔乳腺癌检测示范项目中，对10128名无症状女性进行了为期五年的筛查，评估她们的病情，结果在35至74岁的女性中发现了163例乳腺癌。确诊为癌症的患者中，34%年龄小于50岁；31%的浸润性癌患者在诊断时已有腋窝转移。在年轻患者中，在定期筛查间隔期发现的癌症更常见于转移性癌症。微小乳腺癌在筛查人群中（29%）比未筛查人群（不到5%）更普遍，并且在各年龄组的受筛查者中出现频率相似。对50岁以下女性进行筛查可使乳腺癌在有利阶段得到更早诊断和治疗，这与年龄较大的受筛查者情况相当。
