Wallace D J, Podell T, Weiner J, Klinenberg J R, Forouzesh S, Dubois E L
JAMA. 1981 Mar 6;245(9):934-8. doi: 10.1001/jama.245.9.934.
Six hundred nine private patients with systemic lupus erythematosus were followed up for a mean of ten years. Ninety percent were female; 79% were white. Three hundred sixty-nine received diagnosis before 1970, and 234 after. Three hundred seventy-nine did not have nephritis; 230 did. The overall ten-year survival was 79% (87% without nephritis, 65% with nephritis). Male patients did consistently worse than female patients. No overall white vs nonwhite difference was noted. The presence of nephrotic syndrome at the onset of nephritis was a poor prognostic sign, but its development later was not. Patients younger than 16 years without nephritis have an excellent prognosis. One hundred twenty-eight patients died (82 with nephritis, 46 without nephritis). The most common causes of death were renal disease and sepsis. Improved survival of this series may reflect closer follow-up, better nutritional status, and treatment at earlier stages of disease.
对609例系统性红斑狼疮的私人患者进行了平均为期十年的随访。90%为女性；79%为白人。369例在1970年之前确诊，234例在1970年之后确诊。379例无肾炎，230例有肾炎。总体十年生存率为79%（无肾炎者为87%，有肾炎者为65%）。男性患者的情况始终比女性患者差。未发现白人患者与非白人患者之间存在总体差异。肾炎发病时存在肾病综合征是预后不良的征兆，但后期出现则不是。16岁以下无肾炎的患者预后良好。128例患者死亡（82例有肾炎，46例无肾炎）。最常见的死亡原因是肾脏疾病和败血症。该系列患者生存率的提高可能反映了更密切的随访、更好的营养状况以及疾病早期的治疗。
