Katsuura G, Hirota R, Itoh S
Jpn J Physiol. 1980;30(5):811-4. doi: 10.2170/jjphysiol.30.811.
In order to elucidate the central action mechanism of cholecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, alpha-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats. Intraperitoneal injection of CCK in a dose of 40 U/kg did not produce any significant changes in the monoamine contents. However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.
为阐明胆囊收缩素（CCK）的中枢作用机制，在生理盐水对照、α-甲基对酪氨酸、左旋多巴和帕吉林预处理的大鼠中，观察了该肽对脑中去甲肾上腺素、多巴胺和5-羟色胺含量的影响。腹腔注射剂量为40 U/kg的CCK未引起单胺含量的任何显著变化。然而，由于注意到注射CCK后去甲肾上腺素周转率有增加的趋势，因此不能排除脑单胺参与CCK中枢作用的可能性。
