利多卡因对小鼠脑胺积累和消耗速率的影响。

Lidocaine's influence on the accumulation and depletion rates of mouse brain amines.

作者信息

Ciarlone A E, Smudski J W

出版信息

J Dent Res. 1977 Nov;56(11):1391-4. doi: 10.1177/00220345770560111901.

DOI:10.1177/00220345770560111901

Abstract

Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. alpha Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of alpha methyl-p-tyrosine controls, and no difference for norepinephrine.

摘要

对小鼠大脑进行了血清素、去甲肾上腺素和多巴胺分析。与帕吉林对照组相比，帕吉林加利多卡因处理导致血清素在一小时内的积累速率增加。与α-甲基-对-酪氨酸对照组相比，α-甲基-对-酪氨酸加利多卡因处理导致多巴胺在四小时内的耗竭速率降低，而去甲肾上腺素则无差异。