Violini R, Ricciardelli B, Trimarco A, Violini M, Ramacci C A
Minerva Med. 1980 Nov 3;71(43):3157-64.
It has long been supposed that histamine plays an intemediary rôle in pulmonary hypertension due to hypoxia, though no firm evidence has been collected. Lung and aortic pressure and the blood histamine content in the aorta, pulmonary artery, vena cava inferior, and suprahepatic veins were therefore measured in anaesthetised dogs breathing ambient air, and after 5' administration of a gas mixture containing 8% O2. Lung pressure rose significantly and aortic pressure changed only slightly. Histamine values, however, rose significantly in the pulmonary artery and were unchanged in the aorta after the hypoxic stimulus. In addition, concentrations were higher in the vena cava and unchanged in the suprahepatic veins. These results indicate that histamine is released from skeletal muscle and electively taken up by lung tissue during hypoxia. Its rôle is certainly important, but further elucidation must await the performance of other studies using drugs that selectively block its release from the muscle district.
长期以来，人们一直认为组胺在缺氧引起的肺动脉高压中起中介作用，尽管尚未收集到确凿的证据。因此，对吸入环境空气的麻醉犬以及吸入含8%氧气的混合气体5分钟后的麻醉犬，测量了其肺和主动脉压力以及主动脉、肺动脉、下腔静脉和肝上静脉中的血液组胺含量。肺压力显著升高，而主动脉压力仅略有变化。然而，在缺氧刺激后，肺动脉中的组胺值显著升高，而主动脉中的组胺值未发生变化。此外，下腔静脉中的浓度较高，肝上静脉中的浓度未发生变化。这些结果表明，组胺在缺氧时从骨骼肌释放，并被肺组织选择性摄取。其作用肯定很重要，但必须等待使用能选择性阻断其从肌肉区域释放的药物进行其他研究，才能进一步阐明。
