Lee S R, Britton W M, Rowland G N
Poult Sci. 1980 Nov;59(11):2403-11. doi: 10.3382/ps.0592403.
Broiler chicks fed corn-soy rations supplemented with toxic levels of magnesium from one day of age grew poorly, developed diarrhea, and exhibited characteristic skeletal abnormalities. Tibiae from magnesium intoxicated chicks were shortened, thickened, and bowed. Percent tibial ash was greatly reduced. Upon microscopic examination, the bone lesion appeared rachitic as evidenced by widened and lengthened growth plates, excessive osteoid seams on endochandral bone, and osteoid or bone capped metaphyseal blood vessels with very few associated osteoblasts. Tibial calcium to phosphorus mass ratios decreased while tibial magnesium to phosphorus mass ratios increased concomitantly with increased dietary magnesium. Calcium and phosphorus homeostasis was possibly affected as evidenced by a general decrease in size and cellularity of parathyroid glands and a general increase in size and cellularity of ultimobranchial glands.
从一日龄起就喂食添加了毒性水平镁的玉米 - 大豆日粮的肉鸡生长不良，出现腹泻，并表现出特征性的骨骼异常。镁中毒雏鸡的胫骨变短、变粗且弯曲。胫骨灰分百分比大大降低。显微镜检查时，骨病变呈现佝偻病样，表现为生长板增宽和延长、软骨内骨上有过多类骨质接缝，以及干骺端血管有类骨质或骨帽，且相关成骨细胞极少。随着日粮镁含量增加，胫骨钙磷质量比降低，而胫骨镁磷质量比则相应增加。甲状旁腺的大小和细胞数量普遍减少，而最后鳃体的大小和细胞数量普遍增加，这表明钙和磷的稳态可能受到了影响。
