Magnussen H, Holle J P, Hartmann V, Ahrens J
Prax Klin Pneumol. 1980 Dec;34(12):750-7.
The physiological effect of intravenous application of aminophylline on the mechanics of breathing and the gaseous exchange in persons with bronchial asthma was studied in 7 out-patients before, during and up to 90 minutes after intravenous injection of 0,48 g of Euphillin, and the data were related to the respective serum levels of the drug. The patients suffered from long-standing bronchial asthma, generally associated with moderate airways obstruction. The bronchodilating effect of Euphyllin could be substantiated for the whole time of the trial solely in respect of the changes in oscillatory impedence; the other parameters showed only temporary changes which had disappeard by the end of the trial although the serum levels of aminophylline were in the therapeutic range (mean +/- SD: 12,5 +/- 3,0 microgram/ml). The data indicate that in some patients with bronchial asthma the effect of Euphyllin on lung function is unpredictable. The suggestion is made to measure the responsiveness of the patient to aminophylline by means of simple lung function tests in order to decide whether or not other bronchodilatory substances should be aded to the therapy.
对7名门诊患者静脉注射0.48克氨茶碱前、注射过程中及注射后长达90分钟，研究了静脉应用氨茶碱对支气管哮喘患者呼吸力学和气态交换的生理效应，并将数据与相应的药物血清水平相关联。这些患者患有长期支气管哮喘，通常伴有中度气道阻塞。在整个试验期间，仅就振荡阻抗的变化而言，可证实氨茶碱的支气管扩张作用；其他参数仅显示出暂时变化，尽管氨茶碱血清水平处于治疗范围内（平均±标准差：12.5±3.0微克/毫升），但在试验结束时这些变化已消失。数据表明，在一些支气管哮喘患者中，氨茶碱对肺功能的影响是不可预测的。建议通过简单的肺功能测试来测量患者对氨茶碱的反应性，以决定是否应在治疗中添加其他支气管扩张剂。
