用6-羟基多巴胺耗竭多巴胺可预防甲基苯丙胺诱导的条件性味觉厌恶，但不能预防氯化锂诱导的条件性味觉厌恶。
Dopamine depletion by 6-hydroxydopamine prevents conditioned taste aversion induced by methylamphetamine but not lithium chloride.
作者信息
Wagner G C, Foltin R W, Seiden L S, Schuster C R
出版信息
Pharmacol Biochem Behav. 1981 Jan;14(1):85-8. doi: 10.1016/0091-3057(81)90107-6.
Specific lesions of the central dopaminergic system produced by intraventricular injections of 6-hydroxydopamine with pargyline and desmethylimipramine pretreatment significantly attenuated conditioned taste aversions to a sweetened-condensed milk solution induced by methylamphetamine. Identically treated rats formed an aversion to the milk solution when lithium chloride was utilized. These results suggest that the methylamphetamine-induced aversion is dependent upon intact dopaminergic neurons.
脑室注射6-羟基多巴胺，并预先使用帕吉林和去甲丙咪嗪处理，所产生的中枢多巴胺能系统的特定损伤，显著减弱了由甲基苯丙胺诱导的对加糖炼乳溶液的条件性味觉厌恶。当使用氯化锂时，经过同样处理的大鼠对乳溶液形成了厌恶。这些结果表明，甲基苯丙胺诱导的厌恶依赖于完整的多巴胺能神经元。
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