分离的大鼠和犬肺血管对合成前列腺素内过氧化物（PGH2）类似物的反应性。

Reactivity of isolated rat and canine pulmonary blood vessels to synthetic prostaglandin endoperoxide (PGH2) analogs.

作者信息

Chand N, Altura B M

出版信息

Prostaglandins Med. 1980 Dec;5(6):469-75. doi: 10.1016/0161-4630(80)90070-1.

Abstract

Reactivity and contractility of isolated pulmonary blood vessels of rats and dogs to two synthetic prostaglandin endoperoxide (PGH2) analogs were studied. Canine pulmonary arteries were found to be insensitive to PGH2 analogs (i.e. U-46619 and U-44069) that were tested. In contrast, rat main pulmonary artery (EC50's = 4 x 10(-10)M, respectively) responded to the endoperoxide analogs with potent and concentration-dependent contractile responses. This study demonstrates regional and species-related variability in the reactivity of pulmonary vascular smooth muscles to biologically, highly potent vasoactive agents. Endogenously generated and released PG-endoperoxides (PGH2) may play important roles in the patho-physiology of the pulmonary vasculature.

摘要

研究了大鼠和犬离体肺血管对两种合成前列腺素内过氧化物（PGH2）类似物的反应性和收缩性。发现犬肺动脉对所测试的PGH2类似物（即U-46619和U-44069）不敏感。相比之下，大鼠主肺动脉（EC50分别为4×10^(-10)M）对该内过氧化物类似物产生了强烈的、浓度依赖性的收缩反应。本研究证明了肺血管平滑肌对生物活性高的血管活性药物的反应性存在区域和物种相关的变异性。内源性生成和释放的PG-内过氧化物（PGH2）可能在肺血管系统的病理生理学中发挥重要作用。