O'Dea J D, Agar N S
Res Vet Sci. 1980 Sep;29(2):153-6.
Two merino sheep and two angora goats were subjected to simulated altitudes of up to 5500 m for about 10 h per day for 38 days. Packed cell volume (PCV), haemoglobin (Hb) concentration and red blood cell (RBC) levels of reduced glutathione (GSH) and 2,3-diphosphoglycerate (2,3-DPG) were measured at regular intervals. Mean PCV increased from 33 per cent to 60 per cent in the sheep and from 33 per cent to 45 per cent in the goats. Mean Hb concentration rose from 11.7 g/dl to 23.1 g/dl in the sheep, and from 11.4 g/dl to 16.0 g/dl in the goats. The level of GSH began to rise in the sheep only after the animals were no longer being subjected to the hypoxic stress, increasing by about 20 mg/dl RBC. In the goats, the levels of GSH rose during, as well as after, the period of hypoxic stress, also by about 20 mg/dl RBC. No change in 2,3-DPG levels was found in either species.
将两只美利奴绵羊和两只安哥拉山羊置于高达5500米的模拟海拔高度，每天约10小时，持续38天。定期测量红细胞压积（PCV）、血红蛋白（Hb）浓度以及红细胞（RBC）中还原型谷胱甘肽（GSH）和2,3-二磷酸甘油酸（2,3-DPG）的水平。绵羊的平均红细胞压积从33%增至60%，山羊的则从33%增至45%。绵羊的平均血红蛋白浓度从11.7克/分升升至23.1克/分升，山羊的从11.4克/分升升至16.0克/分升。仅在动物不再遭受低氧应激后，绵羊体内的谷胱甘肽水平才开始上升，每红细胞增加约20毫克/分升。在山羊中，低氧应激期间及之后，谷胱甘肽水平也上升，同样每红细胞增加约20毫克/分升。两种动物的2,3-DPG水平均未发现变化。
