Smith J E, Lee M, Agar N S, Ou D
Am J Vet Res. 1976 Oct;37(10):1135-7.
The affinity of hemoglobin for oxygen did not differ significantly between normal and glutathione-deficient sheep. Although phlebotomy in sheep of both types did not significantly alter the partial pressure values at which hemoglobin is 50% saturated with oxygen, it did increase significantly the erythrocyte glutathione and 2,3-diphosphoglycerate (GSH) and (DPG) concentrations. Because DPG does not bind to sheep hemoglobin, its increase in hypoxic sheep must mean DPG is metabolically controlled in the absence of physiologic effect.
正常绵羊和谷胱甘肽缺乏绵羊的血红蛋白对氧的亲和力没有显著差异。尽管对这两种类型的绵羊进行放血处理并没有显著改变血红蛋白氧饱和度为50%时的分压值，但确实显著提高了红细胞谷胱甘肽（GSH）和2,3 - 二磷酸甘油酸（DPG）的浓度。由于DPG不与绵羊血红蛋白结合，其在低氧绵羊中的增加必然意味着DPG在没有生理效应的情况下受到代谢控制。
