Ardaillou N, Yvart J, Le Bras P, Larrieu M J
Thromb Haemost. 1980 Dec 19;44(3):146-9.
The catabolism of human fragment D, (FgD), obtained by plasmin digestion of fibrinogen has been investigated in normal subjects and patients with liver cirrhosis and the results compared with those obtained for fibrinogen (Fg). Fg was labelled with I-125 and Fg D with I-131 using the chloramine T method. The plasma disappearance curves of both labelled proteins fitted a two exponential curve. In controls the plasma clearance rate of Fg D was greater than that of Fg as shown by the marked difference between the half-lives of these two tracers: 8,9 and 83,5 hours for Fg D and Fg respectively. The fractional catabolic rate of Fg D was 3.38 times the plasma pool per day. In nine patients with liver cirrhosis, catabolism of Fg was not modified. In contrast, catabolism of Fg D was significantly reduced with a half life of 13.0 hours and a low fractional catabolic rate. These results suggest the role of the liver in the catabolism of Fg D in man.
通过纤维蛋白原的纤溶酶消化获得的人D片段（FgD）的分解代谢，已在正常受试者和肝硬化患者中进行了研究，并将结果与纤维蛋白原（Fg）的结果进行了比较。使用氯胺T法用I-125标记Fg，用I-131标记FgD。两种标记蛋白的血浆消失曲线均符合双指数曲线。在对照组中，FgD的血浆清除率高于Fg，这两种示踪剂的半衰期存在明显差异：FgD和Fg的半衰期分别为8.9小时和83.5小时。FgD的分解代谢率为每天3.38倍血浆池。在9例肝硬化患者中，Fg的分解代谢未改变。相比之下，FgD的分解代谢显著降低，半衰期为13.0小时，分解代谢率较低。这些结果提示肝脏在人FgD分解代谢中的作用。
