Krug H, Głuszek J, Smarsz C, Jasiński K
Cor Vasa. 1977;19(4-5):281-90.
The catabolism of fibrinogen was studied during the first week of acute myocardial infarction in twenty-three patients and in ten control patients. A trial was carried out using 125I-labelled fibrinogen. After myocardial infarction, the mean biological half-life of fibrinogen was 62.5 +/- 10.0 h and the mean plasma loss of fibrinogen per 24 hours was 34.1 +/- 6.9% of the intravascular fibrinogen pool. In the control group, respective values of 89.6 +/- 9.9 and 23.4 +/- 3.9% were obtained, which were in close agreement with published values for the normal catabolism of fibrinogen. The fractional catabolic rate of the intravascular fibrinogen pool was significantly increased in patients with myocardial infarction in contrast to the absolute plasma loss of fibrinogen which appeared to be the same as in subjects with normal plasma fibrinogen concentration. Possible explanations of the accelerated catabolism of fibrinogen after myocardial infarction are discussed.
对23例急性心肌梗死患者和10例对照患者在急性心肌梗死的第一周内进行了纤维蛋白原分解代谢的研究。采用125I标记的纤维蛋白原进行了一项试验。心肌梗死后，纤维蛋白原的平均生物半衰期为62.5±10.0小时，每24小时纤维蛋白原的平均血浆丢失量为血管内纤维蛋白原池的34.1±6.9%。在对照组中，分别得到89.6±9.9和23.4±3.9%的值，这与已发表的纤维蛋白原正常分解代谢的值密切一致。与纤维蛋白原的绝对血浆丢失量相比，心肌梗死患者血管内纤维蛋白原池的分解代谢率显著增加，而纤维蛋白原的绝对血浆丢失量似乎与血浆纤维蛋白原浓度正常的受试者相同。讨论了心肌梗死后纤维蛋白原分解代谢加速的可能原因。
