• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

癌症患者中效应器活性降低的小型化全血ADCC检测

Miniaturized whole blood ADCC assay of depressed effector activity in cancer patients.

作者信息

Sasaki M, Looman B, Terasaki P I

出版信息

Tissue Antigens. 1980 Mar;15(3):225-30. doi: 10.1111/j.1399-0039.1980.tb00911.x.

DOI:10.1111/j.1399-0039.1980.tb00911.x
PMID:7466771
Abstract

The ADCC test has been miniaturized to use 0.05 ml of whole blood per test as ADCC effectors. A linear dose response was shown by dilutions of 0.05 ml of blood down to a 1:16 dilution. ADCC effector activities of 40 patients with lung cancer and four with leukemia were markedly less than the activity of 200 normal subjects. Melanoma patients did not have comparable statistically significant loss of ADCC activity.

摘要

ADCC试验已小型化,每次试验使用0.05毫升全血作为ADCC效应细胞。从0.05毫升血液稀释至1:16稀释度呈线性剂量反应。40例肺癌患者和4例白血病患者的ADCC效应细胞活性明显低于200例正常受试者的活性。黑色素瘤患者的ADCC活性没有统计学上可比的显著降低。

相似文献

1
Miniaturized whole blood ADCC assay of depressed effector activity in cancer patients.癌症患者中效应器活性降低的小型化全血ADCC检测
Tissue Antigens. 1980 Mar;15(3):225-30. doi: 10.1111/j.1399-0039.1980.tb00911.x.
2
Antibody-dependent cell-mediated cytotoxicity in human cancer: characterization of patient leukocyte activity and treatment effects.人类癌症中的抗体依赖性细胞介导的细胞毒性:患者白细胞活性及治疗效果的特征
Cancer. 1982 Jan 15;49(2):251-60. doi: 10.1002/1097-0142(19820115)49:2<251::aid-cncr2820490210>3.0.co;2-7.
3
Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells.嵌合和人源化抗HM1.24抗体介导针对肺癌细胞的抗体依赖性细胞毒性。
Lung Cancer. 2009 Jan;63(1):23-31. doi: 10.1016/j.lungcan.2008.04.009. Epub 2008 Jun 3.
4
Complement potentiation of phagocyte-mediated ADCC of HSV-infected corneal cells.补体增强吞噬细胞介导的单纯疱疹病毒感染角膜细胞的抗体依赖细胞介导的细胞毒性作用。
Invest Ophthalmol Vis Sci. 1984 Apr;25(4):440-6.
5
Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP).人嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫(HAM/TSP)中的抗体依赖性细胞介导的细胞毒性(ADCC)
J Neurol Sci. 1996 Oct;142(1-2):65-9. doi: 10.1016/0022-510x(96)00149-9.
6
Modulation of natural killing activity by lymphoblastoid interferon in cancer patients.淋巴母细胞干扰素对癌症患者自然杀伤活性的调节作用。
J Biol Response Mod. 1983;2(2):151-65.
7
Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. II. Normal antibody-dependent cellular cytotoxicity (ADCC) mediated by effector cells defective in natural killer (NK) cytotoxicity.获得性免疫缺陷综合征(AIDS)及AIDS相关综合征患者自然杀伤(NK)细胞活性缺陷的机制。II. 由自然杀伤细胞(NK)细胞毒性缺陷的效应细胞介导的正常抗体依赖性细胞毒性(ADCC)
J Immunol. 1987 Jul 1;139(1):55-60.
8
Interleukin-2 enhancement of monoclonal antibody-mediated cellular cytotoxicity against human melanoma.白细胞介素-2增强单克隆抗体介导的针对人黑色素瘤的细胞毒性作用。
Cancer Res. 1987 Dec 15;47(24 Pt 1):6600-5.
9
51Cr release assay of antibody-dependent cell-mediated cytotoxicity (ADCC).抗体依赖的细胞介导的细胞毒性(ADCC)的51铬释放试验。
Curr Protoc Immunol. 2001 May;Chapter 7:Unit 7.27. doi: 10.1002/0471142735.im0727s08.
10
Human antibody-dependent cellular cytotoxicity. Isolation and identification of a subpopulation of peripheral blood lymphocytes which kill antibody-coated autologous target cells.人抗体依赖性细胞毒性。外周血淋巴细胞亚群的分离与鉴定,该亚群可杀伤抗体包被的自体靶细胞。
J Clin Invest. 1975 Dec;56(6):1580-6. doi: 10.1172/JCI108240.

引用本文的文献

1
Defective neutrophil function in low-birth-weight, premature infants.低体重早产儿中性粒细胞功能缺陷
J Clin Pathol. 1981 Apr;34(4):366-70. doi: 10.1136/jcp.34.4.366.