Al-Hadithy H, Addison I E, Goldstone A H, Cawley J C, Shaw J C
J Clin Pathol. 1981 Apr;34(4):366-70. doi: 10.1136/jcp.34.4.366.
A whole-blood technique was used to measure simultaneously neutrophil migration, uptake, and killing of candida in 27 premature infants of low birth weight (less than 1500 g). Neutrophil migration was consistently reduced, especially in the first two weeks of life. Phagocytosis was also reduced, particularly in the first week of life and in sick patients. Killing was usually normal, except in sick patients. The three functions were not altered when the test was performed in normal adult, rather than autologous, plasma, and the reduced migration and uptake are therefore the result of an intrinsic defect of the cell. The results clarify the previous controversy concerning neutrophil function in premature infants and provide an explanation for their increased susceptibility to infection.
采用全血技术同时检测了27例低出生体重（小于1500克）早产儿的中性粒细胞迁移、摄取和杀灭念珠菌的能力。中性粒细胞迁移能力持续降低，尤其是在出生后的头两周。吞噬作用也降低，特别是在出生后的第一周和患病婴儿中。除了患病婴儿外，杀菌能力通常正常。当在正常成人血浆而非自体血浆中进行检测时，这三种功能没有改变，因此迁移和摄取能力降低是细胞内在缺陷的结果。这些结果澄清了先前关于早产儿中性粒细胞功能的争议，并为他们对感染易感性增加提供了解释。
