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[嘧啶衍生物对感染麻疹或脊髓灰质炎病毒小鼠骨髓细胞染色体装置损伤的抗诱变效力]

[Antimutagenic effectiveness of pyrimidine derivatives in lesions of the bone marrow cell chromosome apparatus in mice infected with measles or poliomyelitis viruses].

作者信息

Il'inskikh N N

出版信息

Tsitol Genet. 1980 Nov-Dec;14(6):14-9.

PMID:7466915
Abstract

It is determined that the number of marrow cells with cytogenetic disturbances grows in mice infected with measles or polymyelitis viruses. The level of marrow cells with disturbances is much lower in the mice fed with methyluracilum or pentoxylum before infection. The level of deteriorated cells also decreases when the mice were fed with the mentioned drug after infection. In an analogous experiment with polymyelitis viruses the antimutagenic effect was not determined.

摘要

经测定,感染麻疹病毒或脊髓灰质炎病毒的小鼠体内,出现细胞遗传学紊乱的骨髓细胞数量会增加。在感染前喂食甲基尿嘧啶或戊氧嘧啶的小鼠中,出现紊乱的骨髓细胞水平要低得多。在感染后给小鼠喂食上述药物时,退化细胞的水平也会降低。在一项针对脊髓灰质炎病毒的类似实验中,未确定抗诱变作用。

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