[嘧啶衍生物对大鼠实验性胃溃疡的影响]
[The effect of pyrimidine derivatives on experimental stomach ulcers in rats].
作者信息
Ismagilova A F, Zarudiĭ F S, Lazareva D N, Ismagilova Z F, Savitskiĭ F P, Tropynina Iu G, Davydova V A, Krivonogov V P
机构信息
Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Russia.
出版信息
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):23-5.
PMID:9783103
Abstract
Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.
摘要
对白化大鼠的实验表明，嘧啶衍生物可减轻吲哚美辛、乙酰水杨酸和邻甲酚酞引起的胃黏膜出血性损伤。嘧啶衍生物可防止总酸性磷酸酶活性降低，增加碱性磷酸酶活性，并降低乳酸脱氢酶的活性。
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