[The effect of pyrimidine derivatives on experimental stomach ulcers in rats].

作者信息

Ismagilova A F, Zarudiĭ F S, Lazareva D N, Ismagilova Z F, Savitskiĭ F P, Tropynina Iu G, Davydova V A, Krivonogov V P

机构信息

Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Russia.

出版信息

Eksp Klin Farmakol. 1998 Jul-Aug;61(4):23-5.

Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.