Eustis S L, Nelson D T
Vet Pathol. 1981 Jan;18(1):21-8. doi: 10.1177/030098588101800103.
Of 45 piglets with diarrhea, 28 had coccidiosis, with no evidence of concurrent viral infection. Villous atrophy and necrotic enteritis were the characteristic lesions, and were more severe in piglets with combined viral and coccidial infections than with coccidiosis alone. Necrotic enteritis presumably was caused by bacterial invasion of the villous lamina propria at foci denuded of epithelium by coccidia, viruses or both. Consistent lesions associated with coccidia in piglets not infected by other primary enteric pathogens suggest that coccidia are the cause of significant clinical disease in nursing piglets 6 to 15 days old.
在45头腹泻仔猪中，28头患有球虫病，无并发病毒感染的迹象。绒毛萎缩和坏死性肠炎是特征性病变，在同时感染病毒和球虫的仔猪中比仅感染球虫的仔猪更为严重。坏死性肠炎可能是由细菌侵入球虫、病毒或两者导致上皮剥脱的绒毛固有层病灶引起的。在未感染其他原发性肠道病原体的仔猪中，与球虫相关的一致性病变表明，球虫是6至15日龄哺乳仔猪严重临床疾病的病因。
