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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Schnell J V, Gruger E H, Malins D C

Xenobiotica. 1980 Mar;10(3):229-34. doi: 10.3109/00498258009033749.

Benzo[a]pyrene, 2,6-dimethylnaphthalene, and naphthalene were used as substrates for a coho salmon (Oncorhynchus kisutch) liver microsomal preparation. 2. The apparent Michaelis constants (Km) were as follows: benzo[a]pyrene, 2.1 microM; 2,6-dimethylnaphthalene, 15.3 microM; and naphthalene, 300 microM. 3. The results indicate that the microsomal preparation had a high affinity for 2,6-dimethylnaphthalene. Thus, 2,6-dimethylnaphthalene, an important constituent of petroleum products, is a useful substrate for research on the disposition in vivo and in vitro of xenobiotics introduced into marine environments by petroleum pollution.

苯并[a]芘、2,6 - 二甲基萘和萘被用作银大麻哈鱼（Oncorhynchus kisutch）肝脏微粒体制剂的底物。2. 表观米氏常数（Km）如下：苯并[a]芘为2.1微摩尔；2,6 - 二甲基萘为15.3微摩尔；萘为300微摩尔。3. 结果表明，该微粒体制剂对2,6 - 二甲基萘具有高亲和力。因此，2,6 - 二甲基萘作为石油产品的一种重要成分，是研究因石油污染引入海洋环境中的外源性物质在体内和体外处置情况的有用底物。

Schnell J V, Gruger E H, Malins D C

Xenobiotica. 1980 Mar;10(3):229-34. doi: 10.3109/00498258009033749.

Benzo[a]pyrene, 2,6-dimethylnaphthalene, and naphthalene were used as substrates for a coho salmon (Oncorhynchus kisutch) liver microsomal preparation. 2. The apparent Michaelis constants (Km) were as follows: benzo[a]pyrene, 2.1 microM; 2,6-dimethylnaphthalene, 15.3 microM; and naphthalene, 300 microM. 3. The results indicate that the microsomal preparation had a high affinity for 2,6-dimethylnaphthalene. Thus, 2,6-dimethylnaphthalene, an important constituent of petroleum products, is a useful substrate for research on the disposition in vivo and in vitro of xenobiotics introduced into marine environments by petroleum pollution.

苯并[a]芘、2,6 - 二甲基萘和萘被用作银大麻哈鱼（Oncorhynchus kisutch）肝脏微粒体制剂的底物。2. 表观米氏常数（Km）如下：苯并[a]芘为2.1微摩尔；2,6 - 二甲基萘为15.3微摩尔；萘为300微摩尔。3. 结果表明，该微粒体制剂对2,6 - 二甲基萘具有高亲和力。因此，2,6 - 二甲基萘作为石油产品的一种重要成分，是研究因石油污染引入海洋环境中的外源性物质在体内和体外处置情况的有用底物。