Krug K
Z Gesamte Inn Med. 1980 Nov 15;35(22):809-12.
For the development of an aplastic anaemia a large number of causes is taken into consideration. In our own clinical material of 26 patients in 15 patients none of the up to now known noxae could be established. Recently in the clarification of the picture of the disease important pathophysiological realizations were got. In these cases disturbances of the stem cell compartments, effects through the matrix of the haematopoietic cells and immunological processes have been recognized as significant. --Own investigations concerning the therapy with the anabolic metenolonenanthat (Primobolan-S) yielded approximately the same large number of therapeutic failures and patients with a good result of the treatment or a partial remission in 15 idiopathic and 11 toxically conditioned anaemias. In the partial remissions in most cases a thrombocytopenia continued existing. A therapy lasting at least two months is necessary in order to estimate the result of the therapy. At the present time cannot yet be predicted on which conditions the use of anabolics will be successful.
再生障碍性贫血的发病需考虑多种病因。在我们自己的26例临床病例中，15例患者尚未明确迄今已知的任何致病因素。最近在明确该疾病的情况时，获得了重要的病理生理认识。在这些病例中，干细胞区室的紊乱、造血细胞基质的作用以及免疫过程已被认为具有重要意义。——关于合成代谢的美睾酮（普丽莫宝）治疗的自身研究显示，在15例特发性贫血和11例中毒性贫血患者中，治疗失败的人数大致相同，而治疗效果良好或部分缓解的患者人数也大致相同。在大多数部分缓解的病例中，血小板减少症持续存在。为评估治疗效果，至少需要持续两个月的治疗。目前尚无法预测在哪些情况下使用合成代谢药物会取得成功。
