Lund N, Jorfeldt L, Lewis D H, Odman S
Acta Anaesthesiol Scand. 1980 Oct;24(5):347-53. doi: 10.1111/j.1399-6576.1980.tb01562.x.
The MDO (Mehrdraht Dortmund oberfläche) oxygen electrode was used in a study of skeletal muscle oxygen pressure fields, presented as histograms, in critically ill patients artificially ventilated with gas mixtures of different oxygen concentrations. The histograms were compared with forearm blood flow measurements performed with strain gauge plethysmography. Local blood flow and permeability-surface area product (PS) were also studied by the simultaneous clearances of 133xenon and 51Cr-EDTA. The histogram distribution type was normal, i.e. approximately Gaussian, at arterial oxygen pressure levels between 10 and 18 kPa. At arterial oxygen pressures outside this range the histogram distribution types were abnormal, i.e. they showed a non-symmetrical distribution of oxygen pressure values, but their mean was approximately the same as in the normal histogram. However, there were significantly higher tissue oxygen pressure mean values in the patients (3.43 kPa) than in a group of healthy human volunteers (2.25 kPa). Mean forearm blood flow and the clearances of 133xenon and 51Cr-EDTA showed marked variations during the measurements both intraindividually and interindividually. Mean forearm blood flow and mean clearances of 133xenon showed opposite trends compared with arterial oxygen pressures. Mean clearances of 51Cr--EDTA and means PS showed only minor variations at the different arterial oxygen pressure levels.
在对使用不同氧浓度气体混合物进行人工通气的重症患者骨骼肌氧压场的研究中，使用了MDO（多特蒙德多丝表面）氧电极，并将氧压场以直方图形式呈现。将这些直方图与通过应变片体积描记法进行的前臂血流测量结果进行了比较。还通过同时清除133氙和51铬-乙二胺四乙酸来研究局部血流和通透表面积乘积（PS）。在动脉氧压水平为10至18 kPa时，直方图分布类型呈正态分布，即近似高斯分布。在该范围之外的动脉氧压下，直方图分布类型异常，即它们显示出氧压值的非对称分布，但其平均值与正常直方图中的平均值大致相同。然而，患者的组织氧压平均值（3.43 kPa）显著高于一组健康人类志愿者（2.25 kPa）。在前臂血流平均值以及133氙和51铬-乙二胺四乙酸的清除率测量过程中，个体内和个体间均显示出明显变化。与动脉氧压相比，前臂血流平均值和133氙清除率平均值呈现相反趋势。在不同动脉氧压水平下，51铬-乙二胺四乙酸清除率平均值和PS平均值仅显示出微小变化。
