Aronow W S
Am Heart J. 1981 Feb;101(2):154-7. doi: 10.1016/0002-8703(81)90658-x.
A double-blind, randomized, crossover study was performed in 15 patients with stable angina to evaluate the effect of breathing carbon monoxide (CO), which raised the carboxyhemoglobin (COHb) from 1.09% to 2.02%, versus breathing compressed, purified air, which lowered the COHb from 1.07% to 1.00% on exercise duration until angina. The exercise duration until angina was 324.5 seconds in the air control period and 330.3 seconds after purified air compared to 321.7 seconds in the CO air control period and 289.7 seconds after CO. Breathing CO to raise the COHb from 1.09% to 2.02% caused a decrease in exercise duration until angina pectoris (p less than 0.001) and a reduction in product of systolic blood pressure times heart rate at the onset of angina (p less than 0.001). These data indicate that a 2% COHb level aggravates angina pectoris due to coronary artery disease.
对15例稳定型心绞痛患者进行了一项双盲、随机、交叉研究，以评估吸入一氧化碳（CO）（使碳氧血红蛋白（COHb）从1.09%升至2.02%）与吸入压缩净化空气（使COHb从1.07%降至1.00%）对运动至心绞痛发作持续时间的影响。在空气对照期，运动至心绞痛发作的持续时间为324.5秒，吸入净化空气后为330.3秒；相比之下，在CO空气对照期为321.7秒，吸入CO后为289.7秒。吸入CO使COHb从1.09%升至2.02%会导致运动至心绞痛发作的持续时间缩短（p<0.001），并使心绞痛发作时收缩压与心率的乘积降低（p<0.001）。这些数据表明，2%的COHb水平会加重冠状动脉疾病所致的心绞痛。
