Response of the left ventricle to stress: effects of exercise, atrial pacing, afterload stress and drugs.

A variety of tests are being utilized today to diagnose the presence of ischemic heart disease, assess the prognosis of myocardial and valvular heart disease and evaluate the effects of various pharmacologic agents on cardiac performance. This review summarizes the current evidence regarding the response of left ventricular performance and size to atrial pacing, afterload stress and various forms of exercise. The responses in normal persons and in subjects with coronary heart disease is reviewed and, when applicable, the effects of various pharmacologic agents on exercise performance in these patient groups are examined.