对两性衰老人类大脑中神经元丢失的生物数学分析，在蓝斑核小脑部分的色素制剂中得到证实。

Biomathematical analysis of the neuronal loss in the aging human brain of both sexes, demonstrated in pigment preparations of the pars cerebellaris loci coerulei.

作者信息

Wree A, Braak H, Schleicher A, Zilles K

出版信息

Anat Embryol (Berl). 1980;160(1):105-19. doi: 10.1007/BF00315653.

Abstract

The pars cerebellaris loci coerulei is a flat accumulation of perikarya representing a subnucleus of the locus coeruleus in the roof of the fourth ventricle of the brain in man. A quantitative study was done on this subnucleus; it comprised 67 specimens from individuals between 11 and 90 years. Nerve cell counts were performed on cleared mounted block preparations. Mathematical analysis of the data was performed using logistic growth functions. The results showed that with advancing age there is a loss of neurons in both sexes. This begins in the female approximately after age 40; in the male already at age 20 (reaching a lower value in old age). The final loss of neurons is more pronounced in the male than in the female. Male and female specimens did not differ in the total number of neurons. In both sexes the left side of the pars cerebellaris loci coerulei contained more neurons than the right.

摘要

脑桥蓝斑核的小脑部是一个由胞体构成的扁平聚集区，代表人类脑第四脑室顶中蓝斑核的一个亚核。对该亚核进行了定量研究；研究包含67个来自11至90岁个体的标本。在透明整装块标本上进行神经细胞计数。使用逻辑斯蒂增长函数对数据进行数学分析。结果显示，随着年龄增长，两性均存在神经元丢失。女性大约在40岁后开始出现这种情况；男性在20岁时就已开始（老年时达到更低值）。男性神经元的最终丢失比女性更明显。男性和女性标本的神经元总数没有差异。在两性中，脑桥蓝斑核小脑部的左侧比右侧含有更多神经元。