Cillard J, Cillard P
Ann Nutr Aliment. 1980;34(3):579-91.
Linoleic, linolenic and arachidonic acids, dispersed at a concentration of 2.5 x 10-3 M in an aqueous media pH 7.3, exhibited increasing of their autoxidation rate in presence of 1.5 x 10-5M alpha-tocopherol or more. Cosidering linolenic and arachidonic acids, prooxidant effect increased with alpha-tocopherol level while for linoleic acid this effect was similar with all alpha-tocopherol concentrations. During the prooxidant reaction, alpha-tocopherol was rapidly oxidized. Its oxidation rate depended on hydroperoxides level. It was the most important in presence of arachidonic acid. After 24 hours, alpha-tocopherol was completly oxidized whatever its initial concentration and the type of the fatty acid. Two oxidation products have been identified : alpha-tocopherylquinone for the most part and a dimer of alpha-tocopherol which was detected at the beginning of the reaction.
亚油酸、亚麻酸和花生四烯酸，以2.5×10⁻³ M的浓度分散在pH 7.3的水性介质中，在存在1.5×10⁻⁵ M或更高浓度的α-生育酚时，其自动氧化速率增加。对于亚麻酸和花生四烯酸，促氧化作用随α-生育酚水平的增加而增强，而对于亚油酸，在所有α-生育酚浓度下这种作用相似。在促氧化反应过程中，α-生育酚迅速被氧化。其氧化速率取决于氢过氧化物水平。在花生四烯酸存在时最为重要。24小时后，无论其初始浓度和脂肪酸类型如何，α-生育酚都被完全氧化。已鉴定出两种氧化产物：大部分为α-生育酚醌，以及在反应开始时检测到的α-生育酚二聚体。
