Edelsten A D, Hughes I A, Oakes S, Gordon I R, Savage D C
Arch Dis Child. 1981 Jan;56(1):40-4. doi: 10.1136/adc.56.1.40.
Height and skeletal maturity scores (TW 2) were determined in 77 diabetic children at diagnosis and again in 48 of them after 1 to 4 years on insulin treatment. Boys, especially those of prepubertal age, were tall at onset. Girls had normal stature, but showed significant growth retardation after treatment. Skeletal maturity was appreciably advanced in both sexes at diagnosis, and on treatment returned to normal only in boys. Girls maintained their advanced skeletal maturity, resulting in an increased disparity between height and skeletal maturity. The results of this study suggest that a prediabetic metabolic abnormality may enhance skeletal maturity in children with diabetes and continues to operate in girls after treatment, despite a reduced growth rate.
对77名糖尿病儿童在诊断时测定了身高和骨骼成熟度评分（TW2），其中48名儿童在接受胰岛素治疗1至4年后再次进行了测定。男孩，尤其是青春期前年龄的男孩，在发病时身高较高。女孩身材正常，但治疗后出现明显的生长发育迟缓。在诊断时，两性的骨骼成熟度均明显提前，治疗后仅男孩的骨骼成熟度恢复正常。女孩维持其提前的骨骼成熟度，导致身高与骨骼成熟度之间的差距增大。本研究结果表明，糖尿病前期的代谢异常可能会提高糖尿病儿童的骨骼成熟度，并且在治疗后女孩中仍持续存在，尽管生长速率降低。
