Hoskins P J, Leslie R D, Pyke D A
Br Med J (Clin Res Ed). 1985 Jan 26;290(6464):278-80. doi: 10.1136/bmj.290.6464.278.
The height at diagnosis of 16 insulin dependent diabetics aged under 19 was compared with that of their unaffected identical cotwins measured at the same time. In eight pairs the diabetic was shorter, and in the remainder the cotwins were the same height. In those diabetics who were shorter than their cotwins at diagnosis the average period of growth delay before diagnosis was at least 35 weeks; by contrast, the mean duration of symptoms was only six weeks. No cause for the growth delay other than the diabetes was known in any of the twins. These findings show that the onset of insulin dependent diabetes may be a slow process, with growth delay occurring several months before symptoms appear.
对16名19岁以下的胰岛素依赖型糖尿病患者在确诊时的身高与其同时测量的未患病的同卵双胞胎的身高进行了比较。在8对双胞胎中，糖尿病患者较矮，其余双胞胎身高相同。在确诊时比其双胞胎矮的糖尿病患者中，确诊前生长延迟的平均时间至少为35周；相比之下，症状的平均持续时间仅为6周。在任何一对双胞胎中，除糖尿病外，均未发现生长延迟的其他原因。这些发现表明，胰岛素依赖型糖尿病的发病可能是一个缓慢的过程，生长延迟发生在症状出现前几个月。
