Hayes A H
Arch Intern Med. 1981 Feb 23;141(3 Spec No):301-4. doi: 10.1001/archinte.141.3.301.
Only drug-drug interactions that are believed clinically important and that are primarily pharmacokinetic in nature are discussed in this article. Drugs reported to interact with aspirin are oral anticoagulants, methotrexate, probenecid, and sulfinpyrazone; those that are believed to interact with acetaminophen are propantheline bromide, narcotics, and metoclopramide hydrochloride, as well as food (carbohydrates). Ethyl alcohol, ammonium chloride, antacids, oral antidiabetic agents, corticosteroids, and heparin sodium probably interact with aspirin. Fenoprofen calcium, gold sodium thiomalate, indomethacin, naproxen, penicillin, phenylbutazone, phenytoin sodium, and spironolactone may also cause such interactions. Ethyl alcohol, beta-adrenergic blockers, oral anticoagulants, chlorpromazine hydrochloride, and miscellaneous mutual toxicities may cause interactions with acetaminophen. The concomitant use of drugs that are believed to interact importantly with either aspirin or acetaminophen should be avoided when designing a treatment regimen. The remaining agents discussed here (of doubtful importance in man) demand careful monitoring in difficult clinical situations and must be submitted to further controlled studies.
本文仅讨论那些临床认为重要且主要为药代动力学性质的药物相互作用。据报道，与阿司匹林相互作用的药物有口服抗凝剂、甲氨蝶呤、丙磺舒和磺吡酮；据信与对乙酰氨基酚相互作用的药物有溴丙胺太林、麻醉药、盐酸甲氧氯普胺以及食物（碳水化合物）。乙醇、氯化铵、抗酸剂、口服抗糖尿病药、皮质类固醇和肝素钠可能与阿司匹林相互作用。芬诺洛芬钙、硫代苹果酸金钠、吲哚美辛、萘普生、青霉素、保泰松、苯妥英钠和螺内酯也可能引起此类相互作用。乙醇、β-肾上腺素能阻滞剂、口服抗凝剂、盐酸氯丙嗪以及其他相互毒性可能与对乙酰氨基酚发生相互作用。在设计治疗方案时，应避免同时使用据信与阿司匹林或对乙酰氨基酚有重要相互作用的药物。此处讨论的其余药物（对人体重要性存疑）在困难的临床情况下需要仔细监测，并且必须进行进一步的对照研究。
