Wegener's granulomatosis and polymorphic reticulosis--two diseases or one? Experience with 90 patients.

Our experience with 50 patients with Wegener's granulomatosis and 40 patients with polymorphic reticulosis allowed us to compare these two disorders both clinically and histopathologically. Although these conditions are similar in some respects, they are separate and separable entities. The histologic features may be the most useful criteria for differentiation. Wegener's granulomatosis is characterized by the presence of vasculitis and necrotizing granulomas, whereas polymorphic reticulosis is typified by a mixed lymphoid infiltrate with an angiocentric growth pattern. The physician should be aware of the differences between these two disorders and should understand the implications of both conditions.