Velican D, Velican C
Atherosclerosis. 1981 Jan-Feb;38(1-2):39-50. doi: 10.1016/0021-9150(81)90102-7.
In an unselected population sample of Bucharest, including 536 subjects (284 males and 252 females) aged up to 40 years, sex appeared as one of the most important factors influencing the pattern of coronary artery growth and remodelling, as well as the pattern of atherosclerotic involvement. The internal elastic membrane of the female coronary arteries of neonates, children, juveniles and adolescents manifested a lesser tendency to fragment, to interrupt and to exhibit elastolysis than did the corresponding internal elastic membrane of male subjects. In the anterior descending and circumflex arteries, female subjects had less intima than males of similar age. Women developed the first atherosclerotic plaques a decade later than men and at a similar age showed fewer atherosclerotic plaques and atheromas. These sex differences were statistically significant for the anterior descending and circumflex arteries, but not for the right coronary artery. During adulthood, the number of women with a three vessel involvement was half that of men. In successive age groups, the degree of luminal narrowing by atherosclerotic plaques was constantly and consistently lower in female than in male subjects.
在布加勒斯特一个未经挑选的人群样本中，有536名年龄在40岁及以下的受试者（284名男性和252名女性），性别似乎是影响冠状动脉生长和重塑模式以及动脉粥样硬化累及模式的最重要因素之一。新生儿、儿童、青少年和青年女性冠状动脉的内弹性膜比男性相应的内弹性膜出现碎片化、中断和弹性溶解的倾向更小。在前降支和回旋支动脉中，同龄女性的内膜比男性少。女性出现首个动脉粥样硬化斑块的时间比男性晚十年，且在相同年龄时，女性的动脉粥样硬化斑块和粥样瘤较少。这些性别差异在前降支和回旋支动脉中具有统计学意义，但在右冠状动脉中无统计学意义。在成年期，三支血管受累的女性数量是男性的一半。在连续的年龄组中，女性动脉粥样硬化斑块导致的管腔狭窄程度始终低于男性受试者。
