Feiman R, Mena Castro E, Gordillo Paniagua G
Bol Med Hosp Infant Mex. 1980 Nov-Dec;37(6):1085-101.
The blood pressure is the resultant of the relationship of three different factors: cardiac output, peripheral vascular resistance and blood volume. The etiology of hypertension in children is variable; however increased peripheral vascular resistance (renin dependent) and increased blood volume (sodium dependent), play a role in a variable degree in most cases of hypertension. Increased blood volume is the predominant factor in some cases of (acute glomerulonephritis), whereas vasoconstriction is the most important mechanism in others (renal segmental hypoplasia). Therefore, it becomes important to evaluate each individual case in order to approach therapy. Diuretics are indicated in patients with hypertension secondary to hypervolemia, while antihypertensives are more useful in cases with vasoconstriction. The scheme of treatment for acute hypertensive crises followed in the Department of Nephrology of the Hospital Infantil de Mexico is presented by the authors. A review of the most commonly antihypertensives used in Pediatrics is made, regarding mainly mechanisms of action, indications, recommended doses and side effects.
心输出量、外周血管阻力和血容量。儿童高血压的病因多种多样;然而,外周血管阻力增加(肾素依赖性)和血容量增加(钠依赖性)在大多数高血压病例中都不同程度地发挥作用。血容量增加是某些病例(急性肾小球肾炎)的主要因素,而血管收缩则是其他病例(肾节段性发育不全)最重要的机制。因此,为了进行治疗,对每个病例进行评估变得很重要。利尿剂适用于血容量过多继发高血压的患者,而抗高血压药在血管收缩的病例中更有用。作者介绍了墨西哥儿童医院肾病科遵循的急性高血压危象治疗方案。对儿科学中最常用的抗高血压药进行了综述,主要涉及作用机制、适应证、推荐剂量和副作用。