Zoccali C, Maugeri Saccà C, Cerrai T, Delfino D, De Vito M, Mallamaci F
Boll Soc Ital Biol Sper. 1980 Dec 15;56(23):2439-45.
To investigate the mechanisms that sustains arterial hypertension in chronic uremia we performed hemodynamic studies in 13 dialysed uremics by means selective radiocardiography (Donato-Giuntini method). The 5 dialysed patients with dialysis controllable hypertension (GROUP B) had higher cardiac indexes (CI) respect to the 8 dialysed normotensive controls (GROUP A) (CI: Group B 4,250 l/min/m2, Group A 3,610 l/min/m2; p less than 0,05). The higher CI in group B appeared independent from the degree of anemia because the two groups had comparable hematocrit values (Hct:Group B 26,2% Group A 26,4%); On the other hand the slight blood volume expansion we observed in group B (7%) respect to group A hardly explains the observed difference in CI. It is interesting that pulmonary blood volume/total blood volume ratio (PBV/TBV) was significantly higher in dialysed hypertensives (PBV/TBV: Group B 14,26%, Group A 11,15%; p less than 0,05) The higher PBV/TBV can be the result of a decrease in venous compliance and could explain the higher CI in group B; further studies however are warranted to elucidate this point.
为研究慢性尿毒症患者动脉高血压持续存在的机制，我们采用选择性放射心动描记术（多纳托 - 琼蒂尼法）对13例接受透析的尿毒症患者进行了血流动力学研究。5例透析后血压可控的患者（B组）的心脏指数（CI）高于8例透析后血压正常的对照者（A组）（CI：B组4250升/分钟/平方米，A组3610升/分钟/平方米；p＜0.05）。B组较高的CI似乎与贫血程度无关，因为两组的血细胞比容值相当（血细胞比容：B组26.2%，A组26.4%）；另一方面，我们观察到B组相对于A组有轻微的血容量扩张（7%），这几乎无法解释观察到的CI差异。有趣的是，透析后高血压患者的肺血容量/总血容量比值（PBV/TBV）显著更高（PBV/TBV：B组14.26%，A组11.15%；p＜0.05）。较高的PBV/TBV可能是静脉顺应性降低的结果，并且可以解释B组较高的CI；然而，需要进一步研究来阐明这一点。
