血液稀释对神经肌肉阻滞药物效能的影响。
Influence off haemodilution on the potency of neuromuscular blocking drugs.
作者信息
Schuh F T
出版信息
Br J Anaesth. 1981 Mar;53(3):263-5. doi: 10.1093/bja/53.3.263.
PMID:7470362
Abstract
The potencies of suxamethonium, pancuronium, and tubocurarine were increased, as shown by a parallel shift to the left of cumulative dose-response curves, following normovolaemic haemodilution before operation. This is attributed to an increase in cardiac output, to a decrease in protein binding and, in the case of suxamethonium, to a decrease in cholinesterase activity.
摘要
琥珀胆碱、泮库溴铵和筒箭毒碱的效能增强，表现为术前等容血液稀释后累积剂量-反应曲线向左平行移动。这归因于心输出量增加、蛋白结合减少，就琥珀胆碱而言，还归因于胆碱酯酶活性降低。
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