Fedotov V P, Pluzhnikova G N, Khoroshutina E B, Ianakopulu E S, Andrianova L E
Biull Eksp Biol Med. 1980 Dec;90(12):692-4.
Growth hormone (1 microgram/ml) inoculated into the primary culture of rat hepatocytes and incubated for 3 hours at 37 degrees C decreases 2-fold the activity of polynucleotide phosphorylase (PNPase). In the culture of hepatocytes from hypophysectomized rats, the basal activity of PNPase is significantly higher as compared with that in the culture of hepatocytes from intact animals. The most pronounced inhibitory effect of growth hormone on PNPase was seen in the culture of hepatocytes from hypophysectomized animals.
将生长激素（1微克/毫升）接种到大鼠肝细胞原代培养物中，并在37℃下孵育3小时，可使多核苷酸磷酸化酶（PNPase）的活性降低2倍。在垂体切除大鼠的肝细胞培养物中，PNPase的基础活性与完整动物肝细胞培养物中的相比显著更高。生长激素对PNPase的抑制作用在垂体切除动物的肝细胞培养物中最为明显。
