[Features of porphobilinogen synthesis from delta-aminolevulinic acid in the tissues of the internal organs of rats].

The biosynthesis of porphobilinogen by homogenates of the lungs, heart, liver, kidneys, spleen, pancreas and small intestinal tissues was studied in 77 intact and in 68 rats with marked lead poisoning. The activity of ALA dehydratase in the lungs was decreased by 40.3%, in the kidneys by 40%, in the heart by 38.2% and was normal in homogenates of the liver, pancreas and small intestine. In spleen homogenates, the activity was increased by 26.3%. Potential mechanisms of different ALA dehydratase reactions in organs tissues of rats with lead poisoning are discussed.