Fleischer I, Wainstein R, Jovtis S, Colombato L O
Acta Gastroenterol Latinoam. 1978;8(3):191-3.
We relate the experience obtained by treatment of 20 advanced digestive cancer patients, with the association of 5 fluorouracil and methyl-C.C.N.U. Objective response was found in 4 patients (20%). Toxicity consisted of leucopenia in 3 patients, allergic phenomena in 2 and diarrhea in 1 patient. Mean survival is increased in 3 months in responders, when compared with non-responders, although this difference has not statistical value.
我们讲述了对20例晚期消化道癌症患者采用5-氟尿嘧啶与甲基环己亚硝脲联合治疗所获得的经验。4例患者(20%)出现客观缓解。毒性反应包括3例患者出现白细胞减少,2例出现过敏现象,1例出现腹泻。与未缓解者相比,缓解者的平均生存期延长了3个月,尽管这种差异无统计学意义。