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一项随机前瞻性试验，比较5-氟尿嘧啶（NSC-19893）与5-氟尿嘧啶和甲环亚硝脲（NSC-95441）治疗晚期胃肠道癌的疗效。

Randomized prospective trial comparing 5-fluorouracil (NSC-19893) to 5-fluorouracil and methyl-CCNU (NSC-95441) in advanced gastrointestinal cancer.

作者信息

Baker L H, Vaitkevicius V K, Gehan E

出版信息

Cancer Treat Rep. 1976 Jun;60(6):733-7.

PMID:954013
Abstract

The Southwest Oncology Group has confirmed the superiority of 5-fluorouracil (5-FU) and methyl-CCNU versus 5-FU weekly as treatment for patients with advanced gastrointestinal cancers. The drug combination produced a PR rate of 29.3% compared to the single-drug arm rate of 10.6%; however, the two-drug arm produced much more toxicity. Despite the improved response rate no improvement in survival was observed.

摘要

西南肿瘤协作组已证实，对于晚期胃肠道癌患者，5-氟尿嘧啶（5-FU）与甲基环己亚硝脲联合使用优于每周使用5-FU。联合用药组的缓解率为29.3%，而单药组为10.6%；然而，联合用药组产生的毒性要大得多。尽管缓解率有所提高，但未观察到生存率的改善。

相似文献

1
Randomized prospective trial comparing 5-fluorouracil (NSC-19893) to 5-fluorouracil and methyl-CCNU (NSC-95441) in advanced gastrointestinal cancer.一项随机前瞻性试验，比较5-氟尿嘧啶（NSC-19893）与5-氟尿嘧啶和甲环亚硝脲（NSC-95441）治疗晚期胃肠道癌的疗效。
Cancer Treat Rep. 1976 Jun;60(6):733-7.
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A controlled study of 5-fluorouracil versus 5-fluorouracil and methyl-CCNU in advanced gastrointestinal adenocarcinoma.5-氟尿嘧啶与5-氟尿嘧啶联合甲环亚硝脲治疗晚期胃肠道腺癌的对照研究。
Clin Oncol. 1977 Sep;3(3):247-57.
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Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer.亚硝基脲类：治疗晚期胃肠道癌的有效药物。
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[Treatment of advanced digestive cancer with fluorouracil and methyl-CCNU].氟尿嘧啶与甲环亚硝脲治疗晚期消化道癌
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Phase I trial of ftorafur combined with mitomycin C or methyl-CCNU in gastrointestinal cancers.氟尿呋啶联合丝裂霉素C或甲基环己亚硝脲治疗胃肠道癌的I期试验
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5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced colorectal cancer: phase II study utilizing weekly 5-FU.5-氟尿嘧啶（5-FU）、甲基环己亚硝脲及长春新碱治疗晚期结直肠癌：采用每周一次5-FU的II期研究
Cancer Treat Rep. 1976 Nov;60(11):1597-600.
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Randomized trial of melphalan plus 5-fluorouracil (5-FU) versus methyl-CCNU plus 5-FU in patients with advanced colorectal cancer.美法仑联合5-氟尿嘧啶（5-FU）与甲环亚硝脲联合5-FU治疗晚期结直肠癌患者的随机试验。
Cancer Treat Rep. 1978 Mar;62(3):457-9.
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Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU. A Southwest Oncology Group study.晚期胃肠道癌大剂量每周 5-氟尿嘧啶与甲环亚硝脲加每周大剂量 5-氟尿嘧啶治疗的 III 期比较。一项西南肿瘤协作组的研究。
Cancer. 1976 Jul;38(1):1-7. doi: 10.1002/1097-0142(197607)38:1<1::aid-cncr2820380102>3.0.co;2-s.
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Phase II trial of ftorafur with mitomycin C versus ftorafur with methyl-CCNU in untreated colorectal cancer.氟尿嘧啶与丝裂霉素C联合用药对比氟尿嘧啶与甲环亚硝脲联合用药治疗未经治疗的结直肠癌的II期试验。
Cancer Treat Rep. 1978 May;62(5):689-92.
10
Methyl-CCNU (NSCU-95441) versus methyl-CCNU plus cyclophosphamide (NSC-26271) in advanced gastrointestinal cancer.
Cancer Chemother Rep. 1975 Nov-Dec;59(6):1161-2.

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Update in cancer chemotherapy: gastrointestinal cancer--colorectal cancer, Part 2.癌症化疗进展：胃肠道癌——结直肠癌，第2部分
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Clinical trials in colorectal cancer: experience of the Gastrointestinal Tumor Study Group and the Southwest Oncology Group.结直肠癌的临床试验：胃肠道肿瘤研究组和西南肿瘤学组的经验
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