一种类似精氨酸加压催产素的神经肽存在于海生软体动物加州海兔的神经系统中。

An arginine vasotocin-like neuropeptide is present in the nervous system of the marine mollusc Aplysia californica.

作者信息

Moore G J, Thornhill J A, Gill V, Lederis K, Lukowiak K

出版信息

Brain Res. 1981 Feb 9;206(1):213-8. doi: 10.1016/0006-8993(81)90119-0.

Abstract

Radioimmunoassays and high pressure liquid chromatography have been used to demonstrate the presence of an arginine-vasotocin-like peptide (AVT) in the anterior ganglia of Aplysia. Previously, AVT, using similar methods, was found to be present only in vertebrates. AVT when perfused over the abdominal ganglion (10(-6)-10(-12)M) was found to increase the bursting activity of R15, to decrease the bursting activity of L3-L6 and to increase the CNS's suppressive influence over the gill withdrawal reflex evoked by siphon stimulation. The AVT present in the nervous system of Aplysia may mediate long-term suppression of gill reflex behaviors induced by factors such as satiation and, as well, regulate the activity of certain neurosecretory neurons.

摘要

放射免疫测定法和高压液相色谱法已被用于证明海兔前神经节中存在一种类似精氨酸血管加压素的肽（AVT）。此前，使用类似方法发现AVT仅存在于脊椎动物中。当将AVT灌注到腹神经节上（10^(-6)-10^(-12)M）时，发现它会增加R15的爆发活动，降低L3-L6的爆发活动，并增强中枢神经系统对虹吸管刺激诱发的鳃收缩反射的抑制作用。海兔神经系统中存在的AVT可能介导由饱腹感等因素引起的鳃反射行为的长期抑制，并且还能调节某些神经分泌神经元的活动。