类似于血管紧张素及其某些类似物的无脊椎动物神经肽：合成与药理学特性。
Invertebrate neuropeptides resembling vasotocin and some analogues: synthesis and pharmacological properties.
作者信息
Kruszyński M, Manning M, Wo N C, Sawyer W H
机构信息
Department of Biochemistry, Medical College of Ohio, Toledo 43699.
出版信息
Experientia. 1990 Jul 15;46(7):771-3. doi: 10.1007/BF01939964.
The solid phase synthesis of three invertebrate vasopressin-oxytocin homologs: AVP-like factor, F1(1), ([Leu2, Thr4] AVT)2 isolated from subesophageal and thoracic ganglia of Locusta migratoria3, Arg-conopressin-S4. ([Ile2, Arg4] AVT), Lys-conopressin-G4 ([Phe2, Arg4] LVT), both isolated from the venom of fish-hunting marine snails of the genus Conus and six of their analogues is reported. These analogues are: [Arg4] AVT, [Ile2] AVT, [Leu2] AVT, [Phe2, Arg4] AVT, [Arg4] LVT and [Ile2, Arg4] LVT. All peptides were tested for antidiuretic and vasopressor activities.
三种无脊椎动物血管加压素 - 催产素同系物的固相合成：从飞蝗的咽下神经节和胸神经节中分离出的AVP样因子、F1(1)、([亮氨酸2，苏氨酸4]AVT)2 、精氨酸锥螺加压素 - S4 。([异亮氨酸2，精氨酸4]AVT)、赖氨酸锥螺加压素 - G4 ([苯丙氨酸2，精氨酸4]LVT)，二者均从芋螺属捕食鱼类的海蜗牛毒液中分离得到，以及它们的六种类似物。这些类似物为：[精氨酸4]AVT、[异亮氨酸2]AVT、[亮氨酸2]AVT、[苯丙氨酸2，精氨酸4]AVT、[精氨酸4]LVT和[异亮氨酸2，精氨酸4]LVT。对所有肽进行了抗利尿和升压活性测试。
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