Thies R, Foreman R D
Brain Res. 1981 Feb 23;207(1):178-83. doi: 10.1016/0006-8993(81)90690-9.
Neurons in the left upper thoracic spinal cord of cats anesthetized with chloralose and relaxed with succinylcholine were activated by electrical stimulation of sympathetic chains or by pinching of the skin. Most neurons were spontaneously active, and 22 of the 51 neurons studied were antidromically activated from the spinomedullary junction, demonstrating their projection to higher centers. Stimulation of the central cut ends of either cervical vagus resulted in inhibition of firing in 26 neurons, acceleration in 6 neurons, both effects in 2 neurons, and no effect in the remaining 17 neurons. The parameters of stimulation determined whether inhibition of facilitation was produced in the two neurons that showed either effect. Two spinal neurons were fired by vagal stimulation with latencies of 16 and 20 msec. Activity in vagal afferent fibers is believed to impinge upon brain stem structures that have been shown by others to cause descending inhibition (and facilitation) of spinothalamic and spinoreticular neurons. This would provide a mechanism for modulation of sensory information from the cardiopulmonary region.
用氯醛糖麻醉并用琥珀酰胆碱使其松弛的猫，其左上胸段脊髓中的神经元，通过交感链的电刺激或皮肤捏压而被激活。大多数神经元有自发活动，在研究的51个神经元中，有22个可被来自脊髓延髓交界处的逆向激活，表明它们向高级中枢投射。刺激双侧颈迷走神经的中枢切断端，导致26个神经元放电抑制，6个神经元放电加速，2个神经元有两种效应，其余17个神经元无效应。刺激参数决定了在显示出两种效应的两个神经元中是产生抑制还是易化。两个脊髓神经元经迷走神经刺激而放电，潜伏期分别为16和20毫秒。迷走神经传入纤维的活动被认为会影响脑干结构，其他人已证明这些结构会引起脊髓丘脑和脊髓网状神经元的下行抑制（和易化）。这将为调制来自心肺区域的感觉信息提供一种机制。
