Sharp A M, Fraser I S, Robertson S, Turtle J R
Clin Chem. 1981 Apr;27(4):603-4.
We describe a problem in measuring serum testosterone concentrations in the serum of women who are taking danazol. The Diagnostic Products Corporation testosterone radioimmunoassay gives very high apparent testosterone concentrations in these women and the value obtained depends on the volume of serum extracted per assay tube. Chromatography of the serum extracts on Sephadex LH-20, but not on Celite, before radioimmunoassay reduced these high apparent testosterone concentrations to less than that found in normal women.
我们描述了在测量服用达那唑的女性血清中睾酮浓度时遇到的一个问题。诊断产品公司的睾酮放射免疫测定法在这些女性中给出的睾酮表观浓度非常高，且所获得的值取决于每个测定管中提取的血清量。在放射免疫测定之前，将血清提取物在葡聚糖凝胶LH - 20上进行色谱分析（但不在硅藻土上进行），可将这些高表观睾酮浓度降低至低于正常女性中的浓度。
