Cates W, Schulz K F
Contraception. 1980 Nov;22(5):513-25. doi: 10.1016/0010-7824(80)90104-3.
The role of oxytocin in augmenting the uterine activity of second-trimester instillation abortions is controversial. To evaluate the efficacy and safety of oxytocin augmentation, we studied 10,013 women who underwent hypertonic saline instillation procedures and 1,241 women who underwent prostaglandin F2a (PGF2a) instillation procedures in the United States in the period 1971 through 1975. Data were obtained through the Joint Program for the Study of Abortion under the auspices of the Center for Disease Control, a multi-center, prospective, cohort study. We found that concurrent administration of oxytocin was associated with a significantly shorter instillation-to-abortion time for hypertonic saline, but with a significantly longer time for PGF2a. For hypertonic saline, use of concurrent oxytocin did not affect either the success rate or the major complication rate; however, it did not affect the specific type of complication that occurred. For PGF2a, use of concurrent oxytocin was associated with a lower success rate and a higher major complication rate than when PGF2a was used alone; however, the relatively small number of observations and limitations in our study design may have affected our results. When we compared the 2 main abortifacients, even when we controlled for concurrent oxytocin augmentation, unaugmented PGF2a had higher major complication rates than hypertonic saline.
催产素在增强孕中期引产流产子宫活动中的作用存在争议。为评估催产素增强作用的疗效和安全性，我们研究了1971年至1975年期间在美国接受高渗盐水引产手术的10013名女性和接受前列腺素F2a（PGF2a）引产手术的1241名女性。数据通过疾病控制中心主持的堕胎联合研究项目获得，该项目是一项多中心、前瞻性队列研究。我们发现，同时使用催产素与高渗盐水引产至流产的时间显著缩短有关，但与PGF2a引产至流产的时间显著延长有关。对于高渗盐水，同时使用催产素既不影响成功率也不影响主要并发症发生率；然而，它不影响所发生并发症的具体类型。对于PGF2a，与单独使用PGF2a相比，同时使用催产素与较低的成功率和较高的主要并发症发生率有关；然而，我们研究设计中观察数量相对较少以及存在局限性可能影响了我们的结果。当我们比较这两种主要堕胎药物时，即使我们控制了同时使用催产素增强作用，未增强的PGF2a的主要并发症发生率仍高于高渗盐水。
